I have the greatest privilege of being associated with Native cultures of many continents.. thus satisfying my curiosity and desire to travel and the chance to help them with my medical expertise. these notes are from those travels. I am a professor at the University of Havana
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vendredi 13 juillet 2018
MEDITERRANEAN DIET MAY SLOW DOWN RATE OF BONE LOSS IN EUROPEAN WOMEN WITH OSTEOPOROSIS
KEY WORDS EUROPEAN WOMEN WITH ESTABLISHED OSTEOPOROSIS MEDITERRANEAN DIET CAN BE A MODIFIED ONE FOR YOUR COUNTRY. THIS DIET IS A SORT OF NEUTRAL DIET FOR ANY ONE TO FOLLOW
Mediterranean-like dietary pattern with vitamin D3 (10 µg/d)
supplements reduced the rate of bone loss in older Europeans with osteoporosis
at baseline: results of a 1-y randomized controlled trial
The Mediterranean diet (MD) is widely recommended for the
prevention of chronic disease, but evidence for a beneficial effect on bone
health is lacking.
The aim of this study was to examine the effect of a
Mediterranean-like dietary pattern [NU-AGE (New Dietary Strategies Addressing
the Specific Needs of the Elderly Population for Healthy Aging in Europe)] on
indexes of inflammation with a number of secondary endpoints, including bone
mineral density (BMD) and biomarkers of bone and collagen degradation in a 1-y
multicenter randomized controlled trial (RCT; NU-AGE) in elderly Europeans.
An RCT was undertaken across 5 European centers. Subjects in
the intervention group consumed the NU-AGE diet for 1 y by receiving
individually tailored dietary advice, coupled with supplies of foods including
whole-grain pasta, olive oil, and a vitamin D3 supplement
(10 µg/d). Participants in the control group were provided with leaflets on
healthy eating available in their country.
A total of 1294 participants (mean ± SD age: 70.9 ±4.0
y; 44% male) were recruited to the study and 1142 completed the 1-y trial. The
Mediterranean-like dietary pattern had no effect on BMD (site-specific or
whole-body); the inclusion of compliance to the intervention in the statistical
model did not change the findings. There was also no effect of the intervention
on the urinary biomarkers free pyridinoline or free deoxypyridinoline. Serum
25-hydroxyvitamin D significantly increased and parathyroid hormone decreased (P < 0.001) in the MD compared with the
control group. Subgroup analysis of individuals with osteoporosis at baseline
(site-specific BMD T-score ≤ −2.5 SDs) showed that the MD attenuated the
expected decline in femoral neck BMD (n = 24 and
30 in MD and control groups, respectively; P = 0.04)
but had no effect on lumbar spine or whole-body BMD.
1-y intervention of the Mediterranean-like diet together with vitamin D3 supplements (10 µg/d) had no effect on BMD in
the normal age-related range, but it significantly reduced the rate of loss of
bone at the femoral neck in individuals with osteoporosis.