Le cancer bientôt vaincu par des chercheurs israéliens?

Une équipe de scientifiques israéliens affirme qu’ils sont en passe, d’ici une année environ, de mettre au point un médicament capable de guérir différentes sortes de cancer.

Selon le Cancer Research UK, cette maladie a entraîné la mort de 6,9 millions de personnes à travers le monde en 2018.

Alors que des scientifiques britanniques déclaraient récemment que le cancer pourra être vaincu d’ici une vingtaine d’année, ces chercheurs israéliens estiment y arriver beaucoup plus tôt, comme l’affirme Dan Aridor, président du comité directeur de la société Accelerated Evolution Biotechnologies Ltd (AEBi), créée en l’an 2000 dans la Parc scientifique Haïm Weizman, et qui développe ce médicament.

“Il s’agit d’une excellente nouvelle quand on sait qu’environ 18 millions de nouveaux cas de cancer se détectent chaque année”, indique Dan Aridor.

Le traitement en question est appelé MuTaTo (multiobjecvtive Toxin) qui attaquera les cellules cancéreuses sans pratiquement aucun dommage collatéral.

L’équipe de chercheurs indique que ce nouveau médicament agira dès le premier jour et n’aura besoin d’être administré que durant quelques semaines.

Dan Aridor souligne également que ce médicament sera beaucoup moins cher que les traitements actuels.

Le Dr. Ilan Morad, Pdg de la compagnie a expliqué plus en détails que ce médicament luttera aussi contre les mutations des cellules cancéreuses au moyen de trois sortes de peptides (polymères d’acides aminés) ajoutés d’une toxine anti-cancéreuse qui attaqueront et tueront les cellules atteintes.

Ces dernières années, la recherche contre le cancer a permis de réduire la mortalité dans de nombreux pays.

Mais quand le médicament développé par AEBi pourra être commercialisé, il s’agira sans aucun doute d’un tournant historique qui permettra de sauver des millions de vie à travers le monde.

Les dirigeants d’AEBi disent avoir déjà effectué de nombreux tests qui donnent des résultats très satisfaisants et réguliers.

Dans un communiqué, la compagnie AEBi indique : « Le Dr. Ilan Morad a donné durant l’année écoulée trois conférences sur ce sujet lors de congrès en Allemagne et à Boston devant des forums de scientifiques et a obtenu des réactions élogieuses. Récemment, nous avons reçu l’autorisation de l’Office américain des brevets »

THIS IS REPRODUCED FROM A BLOG I RECEIVE DAILY FROM FRANCE 

I THINK THIS ARTICLE WAS WRITTEN BY SHRAGA BLUM

MADE HOMELESS BY TRAVEL: WHAT DO YOU DO FOR A LIVING

I  am grateful whoever the person was, for introducing me to Moritz Thomsen, a beautiful soul, a peace corps volunteer in the 1960s, trying hard to make the life of the poor in the black coast of Ecuador and failing repeatedly and finally writing a beautiful travel book at the age of 75
In his admiring introduction, Paul Theroux writes that "a travel book may be many things, and The Saddest Pleasure seems to be most of them -- not just a report of a journey, but a memoir, an autobiography, a confession, a foray into South American topography and history, a travel narrative, with observations of books, music, and life in general, in short, what the best travel books are, a summing up." 

I remember reading the book while I was visiting Ecuador, up the coast from Guayaquil not far from the scene described in the book. ( I even remember the taste of ceviche and beer by the beach at an ungodly hour, me being not a beer drinker).
I was thinking of Thomsen today
as the snow was falling in Bruselas, Belgica.
Thomsen was born in 1915 into a wealthy American family in Seattle. His namesake was after his grandfather a powerful Washington businessman. Charlie, his father was President of Centennial Mills (Krusteaz Brand) and a multi-millionaire at the turn of the 20th century.^[1][2] As detailed in his memoirs, his relationship with his father was extremely strained, with Thomsen describing the man as "tyrannical."

During World War II, Thomsen served as a B-17 Flying Fortress bombardier in the Eighth Air Force. At age 44 he was working as a farmer in California when he decided to join the Peace Corps. In 1964, at 48 years old, Thomsen came to Ecuador as one of the first volunteers of the Peace Corps . Upon arrival, and after many wanderings, he was assigned on condition of agricultural expert to the small fishing town of Green River, north of the province of Esmeraldas . Thomsen lived for four years in that village, and a total of 35 years in Ecuador. After serving as a volunteer for four years, he remained in Ecuador. He died in 1991 of cholera (from Wiki)

I have led a wandering life, not one without a purpose but combined well my love of travel and cultures, as an Anthropologist with the expertise in metabolic diseases as an Endocrinologist. 

I am on my second trip around the world for 2019, the first one was to the Far East and this would cover South America, as well.

Recently I was asked a most difficult question. What do you do for a living or in australian slang it would be. what do you for a crust?

I try to give as simple answer as possible, just mentioning Cuba, American Indians. But more questions follow and of course I am happy to answer.

There is also the usual question towards the end?

What is that you find most difficult in your lifestyle?

The answer was very easily formulated..

It is not the long trips  Miami to London 8 hours, Paris to Cochin via Tel Aviv and Addis Ababa, many many hours, Narita to Boston 12 1/2 hours..

It is not the long trips. I have learned all the tricks of the trade to make my journey as comfortable as possible. Lounges at airports certainly make it easier, sometimes I may divert my flight through Doha just to enjoy for a few hours the wonderful Al Mourjan Lounge..

(Qatar Airways)

Destinations/

I am at home at most of the destinations that I usually visit (various projects)  Miami Havana London Paris Brussels Haifa Cochin Kuala Lumpur Siem Reap.. and occasionally visit other places Leticia Sao Paolo ..

(Kuala Lumpur, always full of unexpected pleasures)

So the destinations do not bore and I do look forward to specific hotels which have become favourites  Double Tree by Hilton in Kuala Lumpur, Beyond Yangon Boutique Inn in Siem Reap or Amazon BnB in Leticia.. also Marriott Marquis in Doha

(welcome at Marriott Marquis in Doha)

so what is that I dislike most about my lifestyle?

It is the people who refuse to accept my lifestyle as an acceptable alternative!

Why do you waste your time?

Don't they have doctors in Colombia?

You have no money!

I remember well dr Pincus the cardiologist when I was a junior doctor in Melbourne. He said to me, a lot of people are going to criticize you because you stick out like a sore thumb. You would demonstrate to other people what they could be doing with their lives.. 

I am not on an evangelical mission, but I realize that I am very good friends with people who easily accept my lifestyle and enjoy the stories that come with (thank you Dr MW/G!).I know them in various parts of the world ..

Perhaps my friends around the world accept me as I accept their lifestyles and that certainly takes  the conflicts of relationships...  I am never critical of other people's lifestyles but I do respect people who make some effort to make the lives of other people a little better..

PETRIFIED ACCOUNTANTS OF EASTER ISLAND

I had been thinking of Easter Island  Rapa Nui or Ile de Paques Isla de Pascua 
and as if in coincidence I came across a cartoon from a book.
That book itself had a story of its own.
I was visiting Cape Town and the then teacher of mine, Cecil Hellman introduced me to a poet who gave me two of his books, one with caricatures 
this drawing is from one of his books.

why do accountants have such poor reputation, whether deserved or not, all over the world?
I can only tell you that my best friend in Asia, YMC, is an accountant, a teacher of accountancy but she is one of the more interesting asians that you would want to encounter..
So generalizations are not correct but I still wonder why accountants are considered so boring?

SCREAM MUNCH AGONY OF THE TIMES

Oslo and Norway hold special places in my heart. For a naive australian young man visiting northern europe for the first time and incredibly susceptible to the romance of the nordic countries.
I was sitting in the cafeteria of the University/School in Oslo, when I glanced upon a copy of SCREAM, a painting so universally known and identified with.
FROM BBC 27 1 2019

Most of art’s iconic masterpieces are renowned for their beauty. Think Leonardo’s smiling Mona Lisa, Vermeer’s luminous Girl with a Pearl Earring and Botticelli’s nude goddess, Venus.

But there’s one glaring exception in the list of all-time greats: Edvard Munch's The Scream. With its pale, hairless figure holding its head in its hands, mouth agape in a tortured howl, it was perhaps an unlikely candidate to become one of the most recognisable and reproduced images of all time.

The Scream, 1893, Edvard Munch (1863-1944). Oil, tempera and pastel on cardboard | Image: National Gallery of Norway

Yet this visceral, doom-laden work – a reflection of the Norwegian artist’s troubled state of mind at the end of the 19th Century – has grown to permeate every aspect of popular culture, from film and TV to memes and tattoos.

You’ll find adaptations and parodies of it on student bedroom walls, on protesters’ placards and in political cartoons. It’s the first painting to have spawned its own emoji – the ‘face screaming in fear’. It has become the ultimate image of existential crisis, the original Nordic Noir.

“One evening I was walking along a path; the city was on one side and the fjord below,” Munch wrote, describing his inspiration for the painting.

“I felt tired and ill. I stopped and looked out over the fjord — the sun was setting, and the clouds turning blood red.

“I sensed a scream passing through nature; it seemed to me that I heard the scream. I painted this picture, painted the clouds as actual blood. The colour shrieked. This became The Scream.”

An 1895 lithograph print of the work, one of several versions Munch created, is the main draw of a new exhibition, Edvard Munch: Love and Angst, at the British Museum in April. It’s the largest show of Munch’s prints in the UK for 45 years, and will offer a revealing look into his turbulent psyche.

I am not a great fan of Emoji, and very seldom use them, but Scream has its own emoji.

and of course in these days of national anxieties such as the one experienced in USA , cartoons also use the scream as something trapped inside of a person trying to get out, this time at a national level

Munch, struggled with mental illness all his life, having seen members of his family committed to asylum and this depiction of scream of Nature, perhaps so soon after the Krakatoa volcano spilled and coloured the skies, is an inner scream not only of himself but of the humanity , that we are witnessing.

Those visits to Oslo, through rain and snow and sunshine left a deep impression upon me. On my last visit sitting at a cafe from the late 19th century visited by all the intellectuals of that time  (Ibsen Larsen Munch among others), one felt a sense of continuity with life. The past is now and the present had been experienced in the past 

what would be the emoji when this president leaves office? A modern North American Munch would come up with something relevant..

In the meantime, the British Library is hosting a large collection of Munch's prints and my wish is to be there before it closes.

SAUDADE DO AMAZONIA THESE PHOTOS TAKEN ONE YEAR AGO 26.1.2018 LETICIA COLOMBIA

Long time ago I had visited Iquitos on the Peruvian Amazon while I was a student in Miami and had been wanting to go to the Amazon: Colombian and Brasilian
A chance arose a couple of years ago and a chance meeting led me to the TICUNA indians and also a Cuban music teacher living in Puerto Narino.
I have been a regular visitor to the region since then, not all visits had been pleasant. It is not a place you invite city people to come who are bothered by mosquitoes and dirty streets and lack of tasty food and wine..
2018 I went there twice, the one in January was very pleasant and the one in July was a disaster, but all is forgiven.
I hope my relationship with the Ticuna and other Indians along the Amazon continue.

MICROBIOME AND KIDNEY AND OTHER INFLAMMATORY DISEASES

I was requested to present an Introduction to Microbiome and its effect upon (or vice versa) on the Kidney diseases at a health fair being held at a tribal auditorium (one of the tribes to which I am a Consultant Endocrinologist)

My curiosity about the different metabolism of the indigenous people was aroused when I visited the San Blas Islands off the coast of the Republic of Panama, along with Dr M and Mrs G, while we were all at the University of Miami School of Medicine.

 
We noticed that the BP readings were in the 100-110/60-70 mm Hg. The doctor in residence at that time,I remember clearly was, Dr Enrique Chen of Panama City. He also told me that when the Kuna travelled to Panama City their Blood pressure would go up. Needless to say , there was no burden of Diabetes among the KUNA

 Many years later, I had a chance to visit the Tarahuamara or the Running People of the Canon del Cobre in Mexico in the company of my good friend Dr Ian Berger (olav ha shalom)

Not only the Raramuri as they called themselves, thin and muscular, the BP readings and Blood Sugar readings paralleled those of the Kuna.

Why are these traditionally living Indians free of the diseases of civilization? 

With the help of my friend Dr. Stuart we were able to measure the Insulin levels of the Tarahumara as well as the San people of Kalahari (Tsumkwe in Namibia to be precise), seen in the picture below.

 
By the time I reached the isolated villages of the Ticuna along the Colombian Amazon, I had compiled a long list of metabolic differences among the Indigenous peoples of the world.

 but differences in the MICROBIOMES in their guts was not among them, that knowledge was to come later 

 An Australian colleague, Dr Wendy Hoy, had been wondering, why do the native people of Australia suffer an inordinately higher rates of Kidney diseases?
In a series of elegant experiments and observations, she was able to confirm what leading nephrologists including Brenner or Brenner and Richter fame had suspected.

 Indigenous Australians (real ones and not the fake ones who have proliferated in the last two decades) have the same disease burden as the Native Americans.
(A Meskwaki elder said: when the white man has one drop of Indian blood, they claim to be Indian, but if they have lots of black blood, they try and hide it)

 My initial hypothesis was that the FATAL CONTACT of the indigenous people with the Immigrants/Conquistadores/Settlers led to an inflammation in their bodies which gave rise to 
OBESITY
DIABETES
and many other diseases of "civilization"

When I became aware of MICROBIOME and its presence at various levels in different populations, I began to understand the connection between indigenous people and the onslaught of diseases among them.
What are the Microbiome ? 

mi·cro·bi·ome

/ˌmīkrōˈbīōm/

noun

1. 
   

   the microorganisms in a particular environment (including the body or a part of the body).

   "we depend on a vast army of microbes to stay alive: a microbiome that protects us against germs, breaks down food to release energy, and produces vitamins"

   • 
     

     the combined genetic material of the microorganisms in a particular environment.

     "understanding the microbiome—human, animal, and environmental—is as important as the human genome"

 It came as no surprise that the least contacted people had the highest diversity of Microbiome. The greater the diversity lesser the chance of Metabolic Diseases...
In my limited experience on Microbiome among the Indians, most of them have lost their diversity by about 60-70 per cent and i wouldnt be surprised if in larger studies it shows that they have lost even higher percentage. In one patient who was going for Gastrectomy, the microbiome diversity had decreased to 16 per cent!

When I went to work for the Meskwakia as a newly minted Endocrinologist, I couldnt believe what they said.

It is the Food that have made us sick.

Now I do agree, it is the outsiders food that have made them sick.

Wise people, if only others listened to their wisdom!

 I remember telling a Nephrologist that Cholesterol is an indicator of the inflammation in our bodies and he laughed at me!  here is my proof  2018

 Many of the disease processes in the large gut or Colon are related to the imbalance of the Microbiome and these include"
Inflammatory Bowel Disease, Crohn's Disease.
If you look at the prevalence of Autism, there has been a dramatic increase in the incidence, now evidence is slowly coming in to say that it may be related to the lack of balance of Microbiome.

There is no one solution fits all. When I analysed my own microbiome, I realized that I cannot eat Kimchi, Tempeh, Miso or Pickles! 

But there were many other vegetables and fruits (not apple, nor tomato) that I could imbibe on. I was very sorry that couscous, millet, barley were a no no for me, sadly Pomegranate as well (the original fruit of Israel!)..but avacado is fine. I am also forbidden to eat Cane Sugar or Chili Powder.. 

So the prescription which has to come in the form of FOOD and not tablets are very individualized 

As I mentioned, my microbiomes do not like Kimchi but Lepaye and Natto are fine. I am happy about a Masala Dosa and few Idly (south indian rice cake) now and then.

Many of the Indigenous foods are beneficial to their Microbiomes and we dont have enough information about their original diet and microbiome to make concrete recommendations, not yet anyway. But Israeli scientists from Technion in Haifa have promised to help me resolve this question.. I trust them.

Eat more Phenol Rich Food (general advice)

 You really need to know your MICROBIOME before tailoring your recipes.. I analyzed my microbiome which forbids me to eat BlackBerries but BlueBerries are alright!

Future treatment of many of the metabolic diseases would include an analysis of your microbiome and recipes provided which include fruits and vegetables and meat, fish and spices that are beneficial to your gut and heal the disease process.

 The means ± s.d. of the net % increased /year incidence and prevalence of autoimmune diseases worldwide were 19.1±43.1 and 12.5±7.9, respectively. Rheumatic, endocrinological, gastrointestinal and neurological autoimmune diseases revealed the following annual % increases per year: 7.1, 6.3, 6.2, and 3.7, respectively. In all of these, differences between old vs new frequencies were highly significant (p< 0.0001). Comparing various autoimmune diseases, celiac disease increased the most and the highest increase in incidence, comparing old to new surveys is allocated to myasthenia gravis. Despite considerable variations between the countries, celiac, type 1 diabetes and myasthenia gravis frequencies increased the most in , and , respectively. Frequencies of the autoimmune diseases increased significantly in the West and North when compared to East and South, respectively.

Role of Microbiome in Kidney Disease

As Kidney disease progresses, the chemicals alter the microbiota, but changes in the microbiome can initiate kidney dysfunction .

 Israeli scientists at Technion in Haifa and Weizmann Institute in Tel Aviv, lead the world in Microbiome research and the treatment based on microbiome, 
One such treatment is already available to patients with Type 2 Diabetes in which nutritional recommendations and recipes would be provided. 
In the above graph, it shows that it is no longer correct to say: Bananas are better than Cookies for you. Now we have to say, in answer to the question, what is better to eat, Bananas or Cookies, you have to say, I better consult my Microbiome.

Video from Weizmann Institute in Israel.

Thank you all for your attention.

With a Khmer Child in Siem Reap, Cambodia  1.1.2019