samedi 6 juillet 2019


An advantage of having an independent medical practice, that is no office, no calls, no appointments is that one is free to read voraciously and put into practice judiciously what you read for the welfare of the people who come under your care.
Who comes under my care?
I am dedicated to Indigenous peoples and thus involved in projects involving their general health, such as Education about Industrial Food among the Indians along the Amazon river.
In a few years time, we would look back and see the primitive way we looked after our chronic diseases, much like we look back at "leech therapy and bleeding therapy" of our ancestors. Everything has an anthropological view point. Most doctors do not realize that 50% of HEALING is the relationship between the patient and the doctor.
I have the luxury of time with my patients and excellent scientific help from ISRAEL to bring or trying to bring good healing practices based on scientific methods.
In isolated camps of the Indians, we talk about

SNP . single nucleotide polymorphism 
and that is where the future is headed and happy to be part of it. Understanding the natural processes of the disease rather than hiding their symptoms with medications may not be the best for the patient 
so it was nice to read this article about a SNP which may predispose Asians and Europeans to Type 2 Diabetes.

Genetic associations between Transcription Factor 7 Like 2 rs7903146 polymorphism and type 2 diabetes mellitus: a meta-analysis of 115,809 subjects

Diabetology & Metabolic Syndrome201911:56
  • Received: 5 May 2019
  • Accepted: 24 June 2019
  • Published: 



Some genetic association studies tried to investigate potential associations of Transcription Factor 7 Like 2 (TCF7L2) rs7903146 polymorphism with type 2 diabetes mellitus (T2DM). However, the results of these studies were not consistent. Thus, we performed the present meta-analysis to explore associations between TCF7L2 rs7903146 polymorphism and T2DM in a larger pooled population.


Systematic literature research of PubMed, Web of Science and Embase was performed to identify eligible studies for pooled analyses. I2 statistics were employed to assess between-study heterogeneities. If I2 was greater than 50%, random-effect models (REMs) would be used to pool the data. Otherwise, fixed-effect models (FEMs) would be applied for synthetic analyses.


Totally 68 studies with 115,809 subjects were included for analyses. The pooled analyses showed that TCF7L2 rs7903146 (dominant model: p < 0.0001; recessive model: p < 0.0001; over-dominant model: p < 0.0001; allele model: p < 0.0001) polymorphism was significantly associated with susceptibility to T2DM in overall population. Further subgroup analyses revealed similar significant findings in both Asians and Caucasians.


In conclusion, our findings supported that TCF7L2 rs7903146 polymorphism could be used to identify individuals at high risk of developing T2DM in Asians and Caucasians.
PS:  a cultural observation, more and more articles are coming out of CHINA 

I was thinking of my friend MAURITZ van PELT of the NGO in Cambodia and his tireless efforts to combat DIABETES type 2 in Cambodia . Kudos to you, Mauritz. 
While the Cambodians may lack money to determine the SNPs in their population we can use kindness, empathy, understanding and education .. to achieve the same results, as he has, in the developed nations..

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