It was astonishing for me to learn that in recent years 17.5 million americans were being diagnosed with DEPRESSION each year. and the figures are not that far behind in other industrialized nations as well as in societies struggling to develop themselves along the Western Economic Model.
More and more articles are being published to say that the traditional psychiatric medications for depression do not improve the Quality of Life of patients even though there are definitely some benefits.
May be it has something to do with their temporal nature of effectiveness ?
- Article
- Published:
Increased global integration in the brain after psilocybin therapy for depression
Nature Medicine 28, 844–851 (2022)
Abstract
Psilocybin therapy shows antidepressant potential, but its therapeutic actions are not well understood. We assessed the subacute impact of psilocybin on brain function in two clinical trials of depression. The first was an open-label trial of orally administered psilocybin (10 mg and 25 mg, 7 d apart) in patients with treatment-resistant depression. Functional magnetic resonance imaging (fMRI) was recorded at baseline and 1 d after the 25-mg dose. Beck’s depression inventory was the primary outcome measure (MR/J00460X/1). The second trial was a double-blind phase II randomized controlled trial comparing psilocybin therapy with escitalopram. Patients with major depressive disorder received either 2 × 25 mg oral psilocybin, 3 weeks apart, plus 6 weeks of daily placebo (‘psilocybin arm’) or 2 × 1 mg oral psilocybin, 3 weeks apart, plus 6 weeks of daily escitalopram (10–20 mg) (‘escitalopram arm’). fMRI was recorded at baseline and 3 weeks after the second psilocybin dose (NCT03429075). In both trials, the antidepressant response to psilocybin was rapid, sustained and correlated with decreases in fMRI brain network modularity, implying that psilocybin’s antidepressant action may depend on a global increase in brain network integration. Network cartography analyses indicated that 5-HT2A receptor-rich higher-order functional networks became more functionally interconnected and flexible after psilocybin treatment. The antidepressant response to escitalopram was milder and no changes in brain network organization were observed. Consistent efficacy-related brain changes, correlating with robust antidepressant effects across two studies, suggest an antidepressant mechanism for psilocybin therapy: global increases in brain network integration.
Pre Colombian artifacts reveal that Native Americans may have known about this long before this geographic entity became America.
Certainly the trend is towards prescribing Magic Mushrooms or their ingredients in a tablet form for depression..
Didnt the Hippies demonstrate it in the USA in the 1960s?
